Nicotinamide Ribosyl Uptake Mutants in Haemophilus influenzae-Reference-Cited by-同舟云学术

Nicotinamide Ribosyl Uptake Mutants in Haemophilus influenzae

Published:2003-09 Issue:9 Volume:71 Page:5398-5401
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Herbert Mark¹,Sauer Elizabeta²,Smethurst Graeme¹,Kraiβ Anita²,Hilpert Anna-Karina²,Reidl Joachim²

Affiliation:

1. Department of Paediatrics, John Radcliffe Hospital, Headington, Oxford OX3 9DU, United Kingdom

2. Zentrum für Infektionsforschung, Universität Würzburg, 97070 Würzburg, Germany

Abstract

ABSTRACT The gene for the nicotinamide riboside (NR) transporter ( pnuC ) was identified in Haemophilus influenzae . A pnuC mutant had only residual NR uptake and could survive in vitro with high concentrations of NR, but could not survive in vivo. PnuC may represent a target for the development of inhibitors for preventing H. influenzae disease.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.71.9.5398-5401.2003

Reference21 articles.

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