Beyond Self-Resistance: ABCF ATPase LmrC Is a Signal-Transducing Component of an Antibiotic-Driven Signaling Cascade Accelerating the Onset of Lincomycin Biosynthesis-Reference-Cited by-同舟云学术

Beyond Self-Resistance: ABCF ATPase LmrC Is a Signal-Transducing Component of an Antibiotic-Driven Signaling Cascade Accelerating the Onset of Lincomycin Biosynthesis

Published:2021-10-26 Issue:5 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Koberska Marketa¹,Vesela Ludmila¹²,Vimberg Vladimir¹,Lenart Jakub¹,Vesela Jana¹,Kamenik Zdenek³,Janata Jiri³,Balikova Novotna Gabriela¹^ORCID

Affiliation:

1. Institute of Microbiology, The Czech Academy of Sciences, BIOCEV, Vestec, Czech Republic

2. Charles University in Prague, Faculty of Science, Department of Genetics and Microbiology, Prague, Czech Republic

3. Institute of Microbiology, The Czech Academy of Sciences, Prague, Czech Republic

Abstract

Resistance proteins are perceived as mechanisms protecting bacteria from the inhibitory effect of their produced antibiotics or antibiotics from competitors. Here, we report that antibiotic resistance proteins regulate lincomycin biosynthesis in response to subinhibitory concentrations of antibiotics.

Funder

Grantová Agentura České Republiky

Grantová Agentura, Univerzita Karlova

EC | European Regional Development Fund

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.01731-21

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1. 1,003 reference genomes of bacterial and archaeal isolates expand coverage of the tree of life