Intersubtype Human Immunodeficiency Virus Type 1 Superinfection following Seroconversion to Primary Infection in Two Injection Drug Users
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Published:2002-08
Issue:15
Volume:76
Page:7444-7452
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ISSN:0022-538X
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Container-title:Journal of Virology
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language:en
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Short-container-title:J Virol
Author:
Ramos Artur1, Hu Dale J.1, Nguyen Lily1, Phan Kim-Oanh1, Vanichseni Suphak2, Promadej Nattawan1, Choopanya Kachit2, Callahan Margaret1, Young Nancy L.13, McNicholl Janet1, Mastro Timothy D.13, Folks Thomas M.1, Subbarao Shambavi1
Affiliation:
1. Centers for Disease Control and Prevention, Atlanta, Georgia 2. Bangkok Metropolitan Administration, Bangkok 3. Thai MOPH-US CDC Collaboration, Nonthaburi, Thailand
Abstract
ABSTRACT
In this study, we describe two cases of human immunodeficiency virus type 1 (HIV-1) intersubtype superinfection with CRF01_AE and subtype B strains, which occurred in two injection drug users participating in a prospective cohort study in Bangkok, Thailand. In both cases, the superinfecting strain was detected by molecular and serologic analyses several weeks after complete seroconversion to the primary infection with a strain belonging to a different subtype. Superinfection occurred despite specific T-cell and humoral antibody responses to the primary virus. In both cases, cross-subtype immune responses were limited or absent prior to the second infection. These data show that, in some individuals, the quality and quantity of the immune response elicited by primary HIV-1 infection may not protect against superinfection. This finding has important implications for vaccine design. HIV-1 vaccines, at a minimum, will need to include potent, broadly protective, conserved immunogens derived from several group M subtypes.
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
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