20S Proteasome as a Drug Target in Trichomonas vaginalis

Author:

O’Donoghue Anthony J.12ORCID,Bibo-Verdugo Betsaida23,Miyamoto Yukiko4,Wang Steven C25,Yang Justin Z.4,Zuill Douglas E.4,Matsuka Shoun2,Jiang Zhenze2,Almaliti Jehad67,Caffrey Conor R.12,Gerwick William H.126,Eckmann Lars14

Affiliation:

1. Center for Discovery and Innovation in Parasitic Diseases, University of California, San Diego, La Jolla, California, USA

2. Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, USA

3. Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA

4. Department of Medicine, University of California, San Diego, La Jolla, California, USA

5. Division of Biological Sciences, University of California, San Diego, La Jolla, California, USA

6. Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California, USA

7. Department of Pharmaceutical Sciences, Faculty of Pharmacy, The University of Jordan, Amman, Jordan

Abstract

Trichomoniasis is a sexually transmitted disease with hundreds of millions of annual cases worldwide. Approved treatment options are limited to two related nitro-heterocyclic compounds, yet resistance to these drugs is an increasing concern. New antimicrobials against the causative agent, Trichomonas vaginalis , are urgently needed.

Funder

HHS | NIH | National Cancer Institute

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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