Plasmid with Colistin Resistance Gene mcr-1 in Extended-Spectrum-β-Lactamase-Producing Escherichia coli Strains Isolated from Pig Slurry in Estonia-Reference-Cited by-同舟云学术

Plasmid with Colistin Resistance Gene mcr-1 in Extended-Spectrum-β-Lactamase-Producing Escherichia coli Strains Isolated from Pig Slurry in Estonia

Published:2016-11 Issue:11 Volume:60 Page:6933-6936
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Brauer Age¹,Telling Kaidi²,Laht Mailis³,Kalmus Piret⁴,Lutsar Irja²,Remm Maido¹,Kisand Veljo³,Tenson Tanel³

Affiliation:

1. Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia

2. Institute of Microbiology, University of Tartu, Tartu, Estonia

3. Institute of Technology, University of Tartu, Tartu, Estonia

4. Institute of Veterinary Medicine and Animal Sciences, Estonian University of Life Sciences, Tartu, Estonia

Abstract

ABSTRACT A plasmid carrying the colistin resistance gene mcr-1 was isolated from a pig slurry sample in Estonia. The gene was present on a 33,311-bp plasmid of the IncX4 group. mcr-1 is the only antibiotic resistance gene on the plasmid, with the other genes mainly coding for proteins involved in conjugative DNA transfer ( taxA , taxB , taxC , trbM , and the pilX operon). The plasmid pESTMCR was present in three phylogenetically very different Escherichia coli strains, suggesting that it has high potential for horizontal transfer.

Funder

Estonian National Program for Health Sciences

Estonian Research Council

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00443-16

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