Role of the Abcg2 Transporter in Secretion into Milk of the Anthelmintic Clorsulon: Interaction with Ivermectin-Reference-Cited by-同舟云学术

Role of the Abcg2 Transporter in Secretion into Milk of the Anthelmintic Clorsulon: Interaction with Ivermectin

Published:2023-05-17 Issue:5 Volume:67 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Blanco-Paniagua Esther¹²,Álvarez-Fernández Laura¹²,Rodríguez-Alonso Andrea²,Millán-Garcia Alicia¹²,Álvarez Ana I.¹²,Merino Gracia¹²^ORCID

Affiliation:

1. Departamento de Ciencias Biomédicas-Fisiología, Facultad de Veterinaria, Universidad de León, León, Spain

2. Instituto de Desarrollo Ganadero y Sanidad Animal (INDEGSAL), Universidad de León, León, Spain

Abstract

Clorsulon is a benzenesulfonamide drug that is effective in treating helminthic zoonoses such as fascioliasis. When used in combination with the macrocyclic lactone ivermectin, it provides high broad-spectrum antiparasitic efficacy.

Funder

MEC | Agencia Estatal de Investigación

Ministerio de Educacion, Cultura y Deporte

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00095-23

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1. Role of the Abcg2 transporter in plasma, milk, and tissue levels of the anthelmintic monepantel in mice;Chemico-Biological Interactions;2024-08

2. Identification of major degradation products of Clorsulon drug substance including its degradation pathways by high resolution mass spectrometry and NMR;Journal of Pharmaceutical and Biomedical Analysis;2024-08

3. Coadministration of ivermectin and abamectin affects milk pharmacokinetics of the antiparasitic clorsulon in Assaf sheep;Frontiers in Veterinary Science;2023-10-18