Multiplicity of <i>bla</i> <sub>KPC</sub> Genes and pKpQIL Plasmid Plasticity in the Development of Ceftazidime-Avibactam and Meropenem Coresistance in Klebsiella pneumoniae Sequence Type 307-Reference-Cited by-同舟云学术

Multiplicity of bla _KPC Genes and pKpQIL Plasmid Plasticity in the Development of Ceftazidime-Avibactam and Meropenem Coresistance in Klebsiella pneumoniae Sequence Type 307

Published:2023-08-17 Issue:8 Volume:67 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Arcari Gabriele¹,Polani Riccardo¹,Santilli Stefania²,Capitani Valerio¹,Sacco Federica¹²,Bruno Francesco¹,Garcia-Fernandez Aurora³^ORCID,Raponi Giammarco²⁴,Villa Laura³,Gentile Giuseppe⁵,Carattoli Alessandra¹^ORCID

Affiliation:

1. Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy

2. Complex Operating Unit of Microbiology and Virology, Policlinico Umberto I, Rome, Italy

3. Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy

4. Department of Public Health, Sapienza University of Rome, Rome, Italy

5. Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

Abstract

In 2021, Klebsiella pneumoniae sequence type 307 (ST307) strains causing pulmonary and bloodstream infections identified in a hospital in Rome, Italy, reached high levels of resistance to ceftazidime-avibactam (CZA). One of these strains reached high levels of resistance to both CZA and carbapenems and carried two copies of bla KPC-3 and one copy of bla KPC-31 located on plasmid pKpQIL.

Funder

Ministero dell'Istruzione, dell'Università e della Ricerca

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00368-23

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