Regression of a Murine Gammaherpesvirus 68-Positive B-Cell Lymphoma Mediated by CD4 T Lymphocytes

Author:

Robertson Kevin A.1,Usherwood Edward J.1,Nash Anthony A.1

Affiliation:

1. Department of Veterinary Pathology, University of Edinburgh, Edinburgh EH9 1QH, United Kingdom

Abstract

ABSTRACT Murine gammaherpesvirus 68-infected S11 cells were injected subcutaneously into nude mice. Adoptively transferred restimulated lymphocytes consistently elicited the regression of S11 tumors. CD4 T lymphocytes were most effective in preventing tumor formation, and immunohistochemistry highlighted populations of CD4 T cells in regressing tumors.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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