Protection of Mice Against Vaccinia Virus by Bacterial Infection and Sustained Stimulation with Specific Bacterial Antigens-Reference-Cited by-同舟云学术

Protection of Mice Against Vaccinia Virus by Bacterial Infection and Sustained Stimulation with Specific Bacterial Antigens

Published:1973-01 Issue:1 Volume:7 Page:62-67
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Allen Emma G.¹,Mudd Stuart²

Affiliation:

1. Department of Microbiology and Immunology, State University of New York, Downstate Medical Center, Brooklyn, New York 11203

2. Philadelphia General Hospital and the Veterans Administration Hospital, Philadelphia, Pennsylvania 19104

Abstract

In these experiments, mice which have a strong delayed-type hypersensitivity to mycobacteria were found, when elicited with old tuberculin, to be more resistant to intravenous vaccinia virus challenge than controls. This was manifest as protection from killing when large amounts of virus were injected, or as significantly less tail swelling and damage as well as lower titers of infectious virus when a lesser inoculum was used. Preliminary experiments indicate that animals sensitized with Staphylococcus aureus and elicited with phage lysate of staphylococcus are also more resistant to vaccinia infection.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.7.1.62-67.1973

Reference28 articles.

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