Predictive Value of Direct Disk Diffusion Testing from Positive Blood Cultures in a Children’s Hospital and Its Utility in Antimicrobial Stewardship

Author:

Savage Timothy J.12ORCID,Rao Shun3,Joerger Jill4,Ozonoff Al32,McAdam Alexander J.4,Sandora Thomas J.12

Affiliation:

1. Division of Infectious Diseases, Boston Children’s Hospital, Boston, Massachusetts, USA

2. Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA

3. Precision Vaccines Program, Division of Infectious Diseases, Boston Children’s Hospital, Boston, Massachusetts, USA

4. Department of Laboratory Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

Abstract

Accurate and early susceptibility results could reduce overuse of broad-spectrum antibiotics for empirical treatment of bacteremia. Direct disk diffusion testing (dDD) using nonstandardized inocula directly from blood cultures could facilitate earlier narrowing of antibiotics.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference26 articles.

1. Antibiotic resistance threats in the United States, 2019

2. Interagency Coordination Group on Antimicrobial Resistance (IACG). 2019. No time to wait: securing the future from drug-resistant infections. World Health Organization Geneva Switzerland. https://www.who.int/antimicrobial-resistance/interagency-coordination-group/final-report/en/.

3. Association of Adverse Events With Antibiotic Use in Hospitalized Patients

4. Randomized Trial of Rapid Multiplex Polymerase Chain Reaction–Based Blood Culture Identification and Susceptibility Testing

5. Implementation of Rapid Molecular Infectious Disease Diagnostics: the Role of Diagnostic and Antimicrobial Stewardship

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