Antileishmanial Activity of an Indole Alkaloid from Peschiera australis-Reference-Cited by-同舟云学术

Antileishmanial Activity of an Indole Alkaloid from Peschiera australis

Published:2001-05 Issue:5 Volume:45 Page:1349-1354
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Delorenzi Jan Carlo¹,Attias Márcia²,Gattass Cerli R.²,Andrade Marcelo³,Rezende Cláudia³,da Cunha Pinto Ângelo³,Henriques Amélia T.⁴,Bou-Habib Dumith C.⁵,Saraiva Elvira M. B.¹

Affiliation:

1. Laboratório de Imunobiologia das Leishmanioses, Departamento de Imunologia-Instituto de Microbiologia,1

2. Laboratório de Ultraestrutura Celular Hertha Meyer, Instituto de Biofı́sica Carlos Chagas Filho,2 and

3. Departamento Quı́mica Orgânica-Instituto de Quı́mica-Universidade Federal do Rio de Janeiro,3 Rio de Janeiro, RJ;

4. Faculdade de Farmácia-Universidade Federal do Rio Grande do Sul, Porto Alegre, RS4; and

5. Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador BA,5Brazil

Abstract

ABSTRACT In this study, we show the leishmanicidal effects of a chloroform fraction (CLF) and a purified indole alkaloid obtained from crude stem extract of Peschiera australis against Leishmania amazonensis , a causative agent of cutaneous leishmaniasis in the New World. In a bioassay-guided chemical fractionation, the leishmanicidal activity in CLF completely and irreversibly inhibited promastigote growth. This fraction was also active against amastigotes in infected murine macrophages. Chemical analysis of CLF identified an iboga-type indole alkaloid coronaridine as one of its major compounds. Coronaridine showed potent antileishmanial activity, inhibiting promastigote and amastigote growth. Promastigotes and amastigotes treated with CLF or coronaridine showed pronounced alterations in their mitochondria as assessed by transmission electron microscopy.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.45.5.1349-1354.2001

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