Persistent Submicroscopic Plasmodium falciparum Parasitemia 72 Hours after Treatment with Artemether-Lumefantrine Predicts 42-Day Treatment Failure in Mali and Burkina Faso

Author:

Beshir Khalid B.1,Diallo Nouhoum2,Somé Fabrice A.3,Sombie Salif4,Zongo Issaka3,Fofana Bakary2,Traore Aliou2,Dama Souleymane2,Bamadio Amadou2,Traore Oumar B.2,Coulibaly Sam A.4,Maurice Ouattara S.5,Diarra Amidou5,Kaboré Jean Moise5,Kodio Aly2,Togo Amadou Hamidou2,Dara Niawanlou2,Coulibaly Moctar2,Dao Francois2,Nikiema Frederic3,Compaore Yves D.3,Kabore Naomie T.3,Barry Nouhoun3,Soulama Issiaka4,Sagara Issaka2,Sirima Sodiomon B.5,Ouédraogo Jean-Bosco3,Djimde Abdoulaye2,Sutherland Colin J.1ORCID

Affiliation:

1. Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom

2. Malaria Research and Training Centre, Department of Epidemiology of Parasitic Diseases, Faculty of Pharmacy, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali

3. Institut de Recherche en Sciences de la Santé Direction Régionale de l’Ouest, Bobo-Dioulasso, Burkina Faso

4. Centre National de Recherche et de Formation sur le Paludisme, Ougadougou, Burkina Faso

5. Groupe de Recherche Action en Santé, Ougadougou, Burkina Faso

Abstract

A recent randomized controlled trial, the WANECAM (West African Network for Clinical Trials of Antimalarial Drugs) trial, conducted at seven centers in West Africa, found that artemether-lumefantrine, artesunate-amodiaquine, pyronaridine-artesunate, and dihydroartemisinin-piperaquine all displayed good efficacy. However, artemether-lumefantrine was associated with a shorter interval between clinical episodes than the other regimens.

Funder

European and Developing Countries Clinical Trials Partnership

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference43 articles.

1. WHO. 2020. World malaria report 2020: 20 years of global progress and challenges. World Health Organization, Geneva, Switzerland.

2. WHO. 2020. Global database on antimalarial drug efficacy and resistance. https://app.powerbi.com/view?r=eyJrIjoiNmRhYWU4ODgtMDI2NC00ZTA0LWE4Y2ItNjVmOGQ5OTY5MTEyIiwidCI6ImY2MTBjMGI3LWJkMjQtNGIzOS04MTBiLTNkYzI4MGFmYjU5MCIsImMiOjh9. Accessed 3 February 2021.

3. Pyronaridine–artesunate or dihydroartemisinin–piperaquine versus current first-line therapies for repeated treatment of uncomplicated malaria: a randomised, multicentre, open-label, longitudinal, controlled, phase 3b/4 trial

4. Reduced ex vivo susceptibility of Plasmodium falciparum after oral artemether–lumefantrine treatment in Mali

5. Continued Low Efficacy of Artemether-Lumefantrine in Angola in 2019

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