Impact of Interleukin-27p28 on T and B Cell Responses during Toxoplasmosis-Reference-Cited by-同舟云学术

Impact of Interleukin-27p28 on T and B Cell Responses during Toxoplasmosis

Published:2019-12 Issue:12 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Park Jeongho¹^ORCID,DeLong Jonathan H.¹,Knox James J.²,Konradt Christoph¹,Wojno Elia D. Tait³,Hunter Christopher A.¹^ORCID

Affiliation:

1. University of Pennsylvania, School of Veterinary Medicine, Philadelphia, Pennsylvania, USA

2. University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA

3. University of Washington, Department of Immunology, Seattle, Washington, USA

Abstract

Interleukin-27 (IL-27) is a heterodimeric cytokine composed of the subunits IL-27p28 and EBi3, and while the IL-27 heterodimer influences T cell activities, there is evidence that IL-27p28 can have EBi3-independent activities; however, their relevance to infection is unclear. Therefore, the studies presented here compared how IL-27p28 transgenics and IL-27p28 −/− mice responded to the intracellular parasite Toxoplasma gondii .

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00455-19

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