Determination of Borrelia Surface Lipoprotein Anchor Topology by Surface Proteolysis-Reference-Cited by-同舟云学术

Determination of Borrelia Surface Lipoprotein Anchor Topology by Surface Proteolysis

Published:2011-11-15 Issue:22 Volume:193 Page:6379-6383
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Chen Shiyong¹,Kumru Ozan S.¹,Zückert Wolfram R.¹

Affiliation:

1. Department of Microbiology, Molecular Genetics & Immunology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, Kansas 66160

Abstract

ABSTRACT We used a surface trypsinolysis assay to probe accessibility of the membrane-proximal N-terminal tether peptides of Borrelia surface lipoproteins OspA and Vsp1. Our findings with both wild-type and mutant proteins are only compatible with the anchoring of these surface lipoproteins in the outer leaflet of the outer spirochetal membrane.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.05849-11

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