Emergence of fexA in Mediating Resistance to Florfenicols in Campylobacter

Author:

Tang Biao12ORCID,Tang Yizhi34,Zhang Ling125,Liu Xiao6,Chang Jiang125,Xia Xiaodong5,Yang Hua12,Shen Zhangqi6

Affiliation:

1. State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Zhejiang Academy of Agricultural Sciences, Hangzhou, China

2. Institute of Quality and Standard for Agro-products, Zhejiang Academy of Agricultural Sciences, Hangzhou, China

3. Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, Animal Disease Prevention, Sichuan University, Chengdu, China

4. Food Safety Key Laboratory of Sichuan Province, College of Life Sciences, Sichuan University, Chengdu, China

5. College of Food Science and Engineering, Northwest Agriculture and Forestry University, Yangling, China

6. Beijing Key Laboratory of Detection Technology for Animal-Derived Food Safety, Beijing Laboratory of Food Quality and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China

Abstract

Florfenicol belongs to a class of phenicol antimicrobials widely used as feed additives and for the treatment of respiratory infections. In recent years, increasing resistance to florfenicol has been reported in Campylobacter spp., the leading foodborne enteric pathogens causing diarrheal diseases worldwide. Here, we reported the identification of fexA , a novel mobile florfenicol resistance gene in Campylobacter . Of the 100 Campylobacter jejuni strains isolated from poultry in Zhejiang, China, 9 were shown to be fexA positive, and their whole-genome sequences were further determined by integration of Illumina short-read and MinION long-read sequencing.

Funder

National Key Research and Development Program of China

State Key Laboratory for Quality and Safety of Agro-products

Youth Program of National Natural Science Foundation of China

Key Research and Development Program of Zhejiang Province

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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