Inhibitory Activities of Lansoprazole against Respiration in Helicobacter pylori-Reference-Cited by-同舟云学术

Inhibitory Activities of Lansoprazole against Respiration in Helicobacter pylori

Published:2001-05 Issue:5 Volume:45 Page:1522-1527
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Nagata Kumiko¹,Sone Nobuhito²,Tamura Toshihide¹

Affiliation:

1. Department of Bacteriology, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501,1 and

2. Department of Biological Engineering, Kyushu Institute of Technology, Iizuka, Fukuoka 820-8502,2 Japan

Abstract

ABSTRACT Lansoprazole and its derivative AG-1789 dose-dependently inhibited cellular respiration by an endogenous substrate and decreased the ATP level in Helicobacter pylori cells. The inhibitory action of lansoprazole and AG-1789 against respiration was specific to substrates such as pyruvate and α-ketoglutarate and similar to the inhibitory action of rotenone, which is an inhibitor for the mitochondrial respiratory chain. Growth inhibition by lansoprazole and AG-1789 as well as by rotenone was augmented at high oxygen concentrations under atmospheric conditions. Since the 50% inhibitory concentrations of these compounds for the respiration were close to their MICs for H. pylori growth, the growth inhibition might be due to respiratory inhibition by these compounds.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.45.5.1522-1527.2001

Reference29 articles.

1. Respiration in Helicobacter pylori is carried out by at least two terminal oxidases, one of which is a novel haem-copper oxidase of the cb-type.;Alderson J.;Gut,1996

2. Investigations into the aerobic respiratory chain of Helicobacter pylori.;Alderson J.;Gut,1997

3. Effects of substances inhibiting or uncoupling respiratory-chain phosphorylation of Helicobacter pylori.;Baer W.;Zentbl. Bakteriol.,1993

4. Partial characterization and effect of omeprazole on ATPase activity in Helicobacter pylori by using permeabilized cells

5. Helicobacter pylori and the pathogenesis of gastroduodenal inflammation.;Blaser M. J.;J. Infect. Dis.,1990

Cited by 15 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Chilean Rhubarb, Gunnera tinctoria (Molina) Mirb. (Gunneraceae): UHPLC-ESI-Orbitrap-MS Profiling of Aqueous Extract and its Anti-Helicobacter pylori Activity;Frontiers in Pharmacology;2021-01-27

2. Rhamnolipid-involved antibiotics combinations improve the eradication of Helicobacter pylori biofilm in vitro: A comparison with conventional triple therapy;Microbial Pathogenesis;2019-06

3. Helicobacter pylori and Antibacterial Agents;Antimicrobial Agents;2014-04-30

4. Anti-Helicobacter pylori actions of CV-6209, a platelet-activating factor receptor antagonist;The Journal of General and Applied Microbiology;2013

5. Synthesis and antimicrobial activities of novel n-substituted 8-(1-alkyl/alkylsulphonyl/alkoxycarbonyl-benzimidazol-2-ylmethoxy)-5-chloroquinolines;Journal of the Serbian Chemical Society;2011