Effect of 14-Membered-Ring Macrolides on Production of Interleukin-8 Mediated by Protease-Activated Receptor 2 in Human Keratinocytes-Reference-Cited by-同舟云学术

Effect of 14-Membered-Ring Macrolides on Production of Interleukin-8 Mediated by Protease-Activated Receptor 2 in Human Keratinocytes

Published:2008-04 Issue:4 Volume:52 Page:1538-1541
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Tsuda Tatsuya¹²,Ishikawa Chika¹,Konishi Hiroe¹,Hayashi Yoshiaki¹,Nakagawa Noboru¹,Matsuki Masato¹,Mizutani Hitoshi²,Yamanishi Kiyofumi¹³

Affiliation:

1. Department of Dermatology

2. Department of Dermatology, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan

3. High-Tech Research Institute, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan

Abstract

ABSTRACT The production of interleukin-8 induced by the activation of protease-activated receptor 2 and its synergism with interleukin-1β were modulated by 14-membered-ring macrolides, namely, roxithromycin, erythromycin, and clarithromycin, in cultured normal human epidermal keratinocytes. Those macrolides may attenuate the protease-activated receptor 2-interleukin-8 axis and thereby modulate proinflammatory responses in the skin.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00140-07

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