Modified Mouse Model of Clostridioides difficile Infection as a Platform for Probiotic Efficacy Studies

Author:

De Wolfe T. J.12ORCID,Kates A. E.23,Barko L.2,Darien B. J.4,Safdar N.23

Affiliation:

1. Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

2. Department of Medicine, Division of Infectious Disease, University of Wisconsin—Madison School of Medicine and Public Health, Madison, Wisconsin, USA

3. William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin, USA

4. Department of Medical Sciences, University of Wisconsin—Madison School of Veterinary Medicine, Madison, Wisconsin, USA

Abstract

Probiotics may represent a promising approach for reducing Clostridioides ( Clostridium ) difficile infections (CDIs). A clinical trial conducted by our group demonstrated that CDI patients undergoing adjunctive treatment with Lactobacillus and Bifidobacterium probiotics had a reduction in diarrheal duration and compositional changes in their stool microbiomes.

Funder

HHS | National Institutes of Health

Wisconsin Alumni Research Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference57 articles.

1. Burden ofClostridium difficileInfection in the United States

2. Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA)

3. Clinical and Healthcare Burden of Multiple Recurrences ofClostridium difficileInfection

4. Centers for Disease Control and Prevention. 2013. Antibiotic resistance threats in the United States, 2013. Centers for Disease Control and Prevention, Atlanta, GA.

5. Department of Veterans Affairs. 2014. VHA directive 1031: antimicrobial stewardship program. Veterans Health Administration, Washington, DC.

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