Modified Mouse Model of Clostridioides difficile Infection as a Platform for Probiotic Efficacy Studies-Reference-Cited by-同舟云学术

Modified Mouse Model of Clostridioides difficile Infection as a Platform for Probiotic Efficacy Studies

Published:2019-07 Issue:7 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

De Wolfe T. J.¹²^ORCID,Kates A. E.²³,Barko L.²,Darien B. J.⁴,Safdar N.²³

Affiliation:

1. Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

2. Department of Medicine, Division of Infectious Disease, University of Wisconsin—Madison School of Medicine and Public Health, Madison, Wisconsin, USA

3. William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin, USA

4. Department of Medical Sciences, University of Wisconsin—Madison School of Veterinary Medicine, Madison, Wisconsin, USA

Abstract

Probiotics may represent a promising approach for reducing Clostridioides ( Clostridium ) difficile infections (CDIs). A clinical trial conducted by our group demonstrated that CDI patients undergoing adjunctive treatment with Lactobacillus and Bifidobacterium probiotics had a reduction in diarrheal duration and compositional changes in their stool microbiomes.

Funder

HHS | National Institutes of Health

Wisconsin Alumni Research Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00111-19

Reference57 articles.

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3. Clinical and Healthcare Burden of Multiple Recurrences ofClostridium difficileInfection

4. Centers for Disease Control and Prevention. 2013. Antibiotic resistance threats in the United States, 2013. Centers for Disease Control and Prevention, Atlanta, GA.

5. Department of Veterans Affairs. 2014. VHA directive 1031: antimicrobial stewardship program. Veterans Health Administration, Washington, DC.

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