TCA and SSRI Antidepressants Exert Selection Pressure for Efflux-Dependent Antibiotic Resistance Mechanisms in Escherichia coli-Reference-Cited by-同舟云学术

TCA and SSRI Antidepressants Exert Selection Pressure for Efflux-Dependent Antibiotic Resistance Mechanisms in Escherichia coli

Published:2022-12-20 Issue:6 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Ou Jin¹,Elizalde Paul¹,Guo Hao-Bo²,Qin Hong²,Tobe Brian T.D.³,Choy John S.¹^ORCID

Affiliation:

1. Department of Biology, The Catholic University of America, Washington, DC, USA

2. Department of Computer Science and Engineering, University of Tennessee at Chattanooga, Chattanooga, Tennessee, USA

3. Department of Psychiatry, Southern California Kaiser Permanente Medical Group, San Diego, California, USA

Abstract

Antidepressants are prescribed broadly for psychiatric conditions to alter neuronal levels of synaptic neurotransmitters such as serotonin and norepinephrine. Two categories of antidepressants are selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs); both are among the most prescribed drugs in the United States.

Funder

National Science Foundation

National Science Foundation Big Data

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.02191-22

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