Discovering Potential Pathogens among Fungi Identified as Nonsporulating Molds

Author:

Pounder June I.1,Simmon Keith E.1,Barton Claudia A.2,Hohmann Sheri L.2,Brandt Mary E.3,Petti Cathy A.124

Affiliation:

1. Associated Regional and University Pathologists, Inc., Institute for Clinical and Experimental Pathology, Salt Lake City, Utah

2. Associated Regional and University Pathologists, Inc., Infectious Diseases Laboratory, Salt Lake City, Utah

3. Centers for Disease Control and Prevention, Mycotic Disease Branch, Atlanta, Georgia

4. University of Utah School of Medicine, Salt Lake City, Utah

Abstract

ABSTRACT Fungal infections are increasing, particularly among immunocompromised hosts, and a rapid diagnosis is essential to initiate antifungal therapy. Often fungi cannot be identified by conventional methods and are classified as nonsporulating molds (NSM).We sequenced internal transcribed spacer regions from 50 cultures of NSM and found 16 potential pathogens that can be associated with clinical disease. In selected clinical settings, identification of NSM could prove valuable and have an immediate impact on patient management.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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