CRISPR/Cas9 Ablation of Integrated HIV-1 Accumulates Proviral DNA Circles with Reformed Long Terminal Repeats-Reference-Cited by-同舟云学术

CRISPR/Cas9 Ablation of Integrated HIV-1 Accumulates Proviral DNA Circles with Reformed Long Terminal Repeats

Published:2021-11-09 Issue:23 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Lai Michele¹²^ORCID,Maori Eyal²,Quaranta Paola¹,Matteoli Giulia¹²,Maggi Fabrizio³⁴,Sgarbanti Marco⁵^ORCID,Crucitta Stefania⁶,Pacini Simone⁷,Turriziani Ombretta⁸⁹^ORCID,Antonelli Guido⁸⁹,Heeney Jonathan L.²,Freer Giulia¹,Pistello Mauro¹⁴^ORCID

Affiliation:

1. Retrovirus Center, Virology Section, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy

2. Laboratory of Viral Zoonotics, Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom

3. Department of Medicine and Surgery, University of Insubria, Varese, Italy

4. Virology Unit, Pisa University Hospital, Pisa, Italy

5. National Institute of Health, Rome, Italy

6. Pharmacology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

7. Hematology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

8. Laboratory of Virology, Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy

9. Pasteur Institute-Cenci Bolognetti Foundation, Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy

Abstract

The excision of HIV-1 provirus from the host cell genome has proven feasible in vitro and, to some extent, in vivo . Among the different approaches, CRISPR/Cas9 is the most promising tool for gene editing.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01358-21

Reference59 articles.

1. A New Class of Medicines through DNA Editing

2. Progress Toward HIV Eradication: Case Reports, Current Efforts, and the Challenges Associated with Cure

3. Harnessing the CRISPR/Cas9 system to disrupt latent HIV-1 provirus

4. Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice

5. SURVEY AND SUMMARY A compilation of cellular transcription factor interactions with the HIV-1 LTR promoter

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