A Neutralizing Antibody Targeting gH Provides Potent Protection against EBV Challenge <i>In Vivo</i>-Reference-Cited by-同舟云学术

A Neutralizing Antibody Targeting gH Provides Potent Protection against EBV Challenge In Vivo

Published:2022-04-27 Issue:8 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Hong Junping¹,Zhong Ling²,Zheng Qingbing¹,Wu Qian¹,Zha Zhenghui¹,Wei Dongmei¹,Chen Haiwen²,Zhang Wanlin²,Zhang Shanshan²,Huang Yang¹,Chen Kaiyun¹,Chen Junyu¹,Li Shaowei¹^ORCID,Zeng Mu-Sheng²^ORCID,Zeng Yi-xin²,Xia Ningshao¹,Zhang Xiao²,Xu Miao²,Chen Yixin¹^ORCID

Affiliation:

1. State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, China

2. State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China

Abstract

Epstein-Barr virus (EBV) is a ubiquitous gammaherpesvirus that establishes lifelong persistence and is related to multiple diseases, including cancers. Neutralizing antibodies (NAbs) have proven to be highly effective in preventing EBV infection and subsequent diseases.

Funder

Guangdong Basic and Applied Basic Research Foundation

Science and Technology Major Projects of Xiamen

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00075-22

Reference64 articles.

1. The structural basis of herpesvirus entry