Breakpoints for Susceptibility Testing Should Not Divide Wild-Type Distributions of Important Target Species-Reference-Cited by-同舟云学术

Breakpoints for Susceptibility Testing Should Not Divide Wild-Type Distributions of Important Target Species

Published:2009-04 Issue:4 Volume:53 Page:1628-1629
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Arendrup Maiken Cavling¹,Kahlmeter Gunnar²,Rodriguez-Tudela Juan Luis³,Donnelly J. Peter⁴

Affiliation:

1. Unit of Mycology and Parasitology, Statens Serum Institut, Copenhagen, Denmark

2. Department of Clinical Microbiology, Central Hospital, Växjö, Sweden

3. Servicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Spain

4. Department of Haematology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

Abstract

ABSTRACT The fluconazole MIC distributions for Candida glabrata from testing 34 different clinical isolates and performing 51 tests on a single isolate mirrored each other. Since what is perceived as biological variation in isolates without resistance mechanisms is mainly methodological variation, breakpoints which divide this distribution not only lack a sound biological basis but also result in poor reproducibility of susceptibility characterization. This makes 2, 4, 8, and possibly 16 μg/ml unsuitable breakpoints for C. glabrata and fluconazole.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01624-08

Reference4 articles.

1. Kahlmeter, G., D. F. Brown, F. W. Goldstein, A. P. MacGowan, J. W. Mouton, A. Osterlund, A. Rodloff, M. Steinbakk, P. Urbaskova, and A. Vatopoulos. 2003. European harmonization of MIC breakpoints for antimicrobial susceptibility testing of bacteria. J. Antimicrob. Chemother.52:145-148.

2. Approved standard M27-A2 2nd ed. 2002

3. EUCAST Technical Note on fluconazole

4. EUCAST Definitive Document EDef 7.1: method for the determination of broth dilution MICs of antifungal agents for fermentative yeasts

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