High-Level Folate Production in Fermented Foods by the B 12 Producer Lactobacillus reuteri JCM1112-Reference-Cited by-同舟云学术

High-Level Folate Production in Fermented Foods by the B 12 Producer Lactobacillus reuteri JCM1112

Published:2008-05-15 Issue:10 Volume:74 Page:3291-3294
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Santos Filipe¹,Wegkamp Arno¹,de Vos Willem M.²,Smid Eddy J.¹,Hugenholtz Jeroen¹

Affiliation:

1. Kluyver Centre for Genomics of Industrial Fermentation, TI Food and Nutrition, and NIZO food research, Kernhemseweg 2, P.O. Box 20, 6710 BA Ede, The Netherlands

2. Laboratory of Microbiology, Wageningen University and Research Centre, Dreijenplein 10, 6703 HB Wageningen, The Netherlands

Abstract

ABSTRACT We observed that Lactobacillus reuteri JCM1112 produces B 12 and folate. However, the folate/B 12 mass ratio found was far below that desired for human consumption (∼170:1). We used metabolic engineering applying genetic and physiological approaches to improve this ratio and developed a generic and natural process that significantly increases folate production.

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/AEM.02719-07

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