Lysostaphin Lysibody Leads to Effective Opsonization and Killing of Methicillin-Resistant Staphylococcus aureus in a Murine Model-Reference-Cited by-同舟云学术

Lysostaphin Lysibody Leads to Effective Opsonization and Killing of Methicillin-Resistant Staphylococcus aureus in a Murine Model

Published:2018-10 Issue:10 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Raz Assaf¹,Serrano Anna¹,Thaker Maneesha¹,Alston Tricia¹,Fischetti Vincent A.¹

Affiliation:

1. Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, New York, USA

Abstract

The cell wall of Gram-positive bacteria contains abundant surface-exposed carbohydrate structures that are highly conserved. While these properties make surface carbohydrates ideal targets for immunotherapy, carbohydrates elicit a poor immune response that results primarily in low-affinity IgM antibodies.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01056-18

Reference73 articles.

1. Community-Associated Methicillin-Resistant Staphylococcus aureus : Epidemiology and Clinical Consequences of an Emerging Epidemic

2. Staphylococcus aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, and Management

3. National Burden of Invasive Methicillin-ResistantStaphylococcus aureusInfections, United States, 2011

4. Invasive Methicillin-Resistant Staphylococcus aureus Infections in the United States

5. Epidemiology of Methicillin‐ResistantStaphylococcus aureus

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