Author:
Beckert Patrick,Hillemann Doris,Kohl Thomas A.,Kalinowski Jörn,Richter Elvira,Niemann Stefan,Feuerriegel Silke
Abstract
ABSTRACTThe ribosomal L3 protein was identified as a novel target in linezolid (LZD)-resistantMycobacterium tuberculosisstrains. Next-generation sequencing confirmedrplCT460C as the sole mutation in an LZD-resistantM. tuberculosisH37Rv strain selectedin vitro. Sequencing analysis revealed therplCT460C mutation in eight further LZD-resistant isolates (threein vitro-selected mutants and five patient isolates, including isolates from three different patients that developed LZD resistance during treatment) but in none of the susceptible control strains (n= 84).
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology