ATG Genes Influence the Virulence of Cryptococcus neoformans through Contributions beyond Core Autophagy Functions-Reference-Cited by-同舟云学术

ATG Genes Influence the Virulence of Cryptococcus neoformans through Contributions beyond Core Autophagy Functions

Published:2018-09 Issue:9 Volume:86 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Ding Hao¹²,Caza Mélissa¹²,Dong Yifei²,Arif Arif A.²,Horianopoulos Linda C.¹²,Hu Guanggan¹²,Johnson Pauline²,Kronstad James W.¹²^ORCID

Affiliation:

1. Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada

2. Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada

Abstract

The process of autophagy is conserved among all eukaryotes from yeast to humans and is mainly responsible for bulk degradation of cellular contents and nutrient recycling during starvation. Autophagy has been suggested to play a role in the pathogenesis of the opportunistic human fungal pathogen Cryptococcus neoformans , potentially through a contribution to the export of virulence factors.

Funder

Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada

Gouvernement du Canada | Canadian Institutes of Health Research

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00069-18

Reference82 articles.

1. Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS

2. Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis