Affiliation:
1. Istituto di Malattie Infettive e Medicina Pubblica1 and
2. Clinica Dermatologica,2 Università degli Studi di Ancona, Ancona, Italy
Abstract
ABSTRACT
A broth macrodilution method following the recommendations established by the National Committee for Clinical Laboratory Standards was used to compare the in vitro activity of posaconazole (PCZ) with that of itraconazole (ITC) against 30 clinical isolates of dermatophytes belonging to six different species. In terms of MICs, PCZ showed an activity equal to that of ITC. MICs of PCZ at which 50% (MIC
50
) and 90% (MIC
90
) of the isolates were inhibited were 0.5 and >4.0 μg/ml, respectively. The MIC
50
and MIC
90
of ITC were 1.0 and >4.0 μg/ml, respectively. However, PCZ showed a more potent fungicidal activity than that of ITC against isolates belonging to the genus
Microsporum
(
P
= 0.03). PCZ merits further investigation as a potentially useful agent for treatment of dermatophytosis.
Publisher
American Society for Microbiology
Cited by
44 articles.
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