Immune response to Campylobacter jejuni and Campylobacter coli in a cohort of children from birth to 2 years of age

Author:

Martin P M1,Mathiot J1,Ipero J1,Kirimat M1,Georges A J1,Georges-Courbot M C1

Affiliation:

1. Institut Pasteur de Bangui, Central African Republic.

Abstract

A cohort of 111 children from Bangui, Central African Republic, was surveyed for enteric Campylobacter infections from birth to the age of 2 years; stools were examined biweekly in these children until 6 months of age and at least four times per year thereafter until 2 years of age and after each diarrheal episode. Blood samples were obtained at birth and at 3, 6, 9, 12, 18, and 24 months of age. Antibodies against glycine-extracted membrane antigens, purified flagella, and cholera toxin (CT) were assayed by an enzyme-linked immunosorbent assay. The results showed that titers of antibody against the three tested antigens increased in children between 6 and 12 months of age and that nearly all children were immunized by the age of 2 years. A significant fall in anti-flagellum (P less than 0.001) and anti-glycine extract antibodies (P less than 0.001) occurred between birth and age 3 months, and children who had Campylobacter infections during the first 6 months of life had significantly (P less than 0.02) less anti-flagellum antibodies at birth than did those who did not have Campylobacter infections during that time. Three-month-interval stratification showed that CT antibody titers at birth were significantly lower in children who developed Campylobacter infection than in controls (P = 0.05). Comparison of the immune response to a single Campylobacter episode showed that 46.6% of children with asymptomatic carriage did not respond to CT while only 5% of children with diarrhea-producing infection did not respond to CT (P less than 0.01), compared with 30% (P = 0.065) and 56% (P less than 0.01), respectively, of the age-matched controls. Antibodies to flagella seem to protect against enteric colonization by Campylobacter jejuni and Campylobacter coli.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference31 articles.

1. Camnpylobacter enteritis in The;Billingham J. D.;Gambia. Trans. R. Soc. Trop. Med. Hyg.,1981

2. Experimental Campylobacter jejiuni infection in humans;Black R. E.;J. Infect. Dis.,1988

3. Caimpylobacter enteritis: clinical and epidemiologic features;Blaser M. J.;Ann. Intern. Med.,1979

4. Camtipvlobacter-jejuni-specific antibodies are elevated in healthy Bangladeshi children;Blaser M. J.;J. Clin. Microbiol.,1985

5. Serologic study of two clusters of infection due to Canmpylobacter jejuni;Blaser M. J.;J. Infect. Dis.,1983

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