Molecular Architecture of Early Dissemination and Massive Second Wave of the SARS-CoV-2 Virus in a Major Metropolitan Area

Author:

Long S. Wesley123ORCID,Olsen Randall J.123,Christensen Paul A.1,Bernard David W.123,Davis James J.45,Shukla Maulik45,Nguyen Marcus45,Saavedra Matthew Ojeda1,Yerramilli Prasanti1,Pruitt Layne1,Subedi Sishir1,Kuo Hung-Che67,Hendrickson Heather1,Eskandari Ghazaleh1,Nguyen Hoang A. T.1,Long J. Hunter1,Kumaraswami Muthiah1ORCID,Goike Jule67,Boutz Daniel8,Gollihar Jimmy18,McLellan Jason S.67ORCID,Chou Chia-Wei67,Javanmardi Kamyab67,Finkelstein Ilya J.679ORCID,Musser James M.123

Affiliation:

1. Center for Molecular and Translational Human Infectious Diseases Research, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, Texas, USA

2. Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York, USA

3. Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA

4. Consortium for Advanced Science and Engineering, University of Chicago, Chicago, Illinois, USA

5. Computing, Environment and Life Sciences, Argonne National Laboratory, Lemont, Illinois, USA

6. Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas, USA

7. Institute for Cell and Molecular Biology, The University of Texas at Austin, Austin, Texas, USA

8. CCDC Army Research Laboratory-South, University of Texas, Austin, Texas, USA

9. Center for Systems and Synthetic Biology, University of Texas at Austin, Austin, Texas, USA

Abstract

There is concern about second and subsequent waves of COVID-19 caused by the SARS-CoV-2 coronavirus occurring in communities globally that had an initial disease wave. Metropolitan Houston, TX, with a population of 7 million, is experiencing a massive second disease wave that began in late May 2020. To understand SARS-CoV-2 molecular population genomic architecture and evolution and the relationship between virus genotypes and patient features, we sequenced the genomes of 5,085 SARS-CoV-2 strains from these two waves. Our report provides the first molecular characterization of SARS-CoV-2 strains causing two distinct COVID-19 disease waves.

Funder

HHS | National Institutes of Health

HHS | NIH | National Institute of Allergy and Infectious Diseases

National Science Foundation

Cancer Prevention and Research Institute of Texas

DOD | Defense Advanced Research Projects Agency

Fondren Foundation

Welch Foundation

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Reference93 articles.

1. World Health Organization. 2020. World Health Organization coronavirus disease 2019 (COVID-19) situation report. https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200420-sitrep-91-covid-19.pdf?sfvrsn=fcf0670b_4. Accessed 21 April 2020.

2. The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2

3. A novel coronavirus outbreak of global health concern

4. Another Decade, Another Coronavirus

5. Country-level factors associated with the early spread of COVID-19 cases at 5, 10 and 15 days since the onset

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