The Glycoprotein of Vesicular Stomatitis Virus Is the Antigen That Gives Rise to and Reacts with Neutralizing Antibody-Reference-Cited by-同舟云学术

The Glycoprotein of Vesicular Stomatitis Virus Is the Antigen That Gives Rise to and Reacts with Neutralizing Antibody

Published:1972-12 Issue:6 Volume:10 Page:1231-1235
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Kelley J. Michael¹,Emerson Suzanne U.¹,Wagner Robert R.¹

Affiliation:

1. Department of Microbiology, The University of Virginia, School of Medicine, Charlottesville, Virginia 22901

Abstract

The glycoprotein, but no other virion protein, of vesicular stomatitis virus was solubilized by the nonionic detergent Triton X-100 in low ionic strength buffer. The solubilized viral glycoprotein induced the synthesis of antibody that formed a single precipitin line with the glycoprotein and that neutralized the infectivity of the virus. The neutralizing activity of the antibody was efficiently blocked by purified glycoprotein.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.10.6.1231-1235.1972

Reference12 articles.

1. Comparison of membrane glycopeptides of Sindbis virus and vesicular stomatitis virus;Burge B. W.;J. Virol,1970

2. Dissection of vesicular stomatitis virus into the infective ribonucleoprotein and immunizing components;Cartwright B.;J. Gen. Virol.,1970

3. The proteins of biologically active subunits of vesicular stomatitis virus;Cartwright B.;J. Gen. Virol.,1970

4. Release of envelope glycoprotein from rabies virus by a nonionic detergent;Gyorgy E.;J. Virol.,1971

5. Proteins of vesicular stomatitis virus. II. Immunological comparisons of viral antigens;Kang C. Y.;J. Virol.,1970

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