Genetic Diversity of Meningococcal Serogroup B Vaccine Antigens among Carriage Isolates Collected from Students at Three Universities in the United States, 2015

Genetic Diversity of Meningococcal Serogroup B Vaccine Antigens among Carriage Isolates Collected from Students at Three Universities in the United States, 2015–2016

Published:2021-05-18 Issue: Volume: Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Marjuki Henju¹^ORCID,Chang How-Yi²,Topaz Nadav³,Whaley Melissa J.¹,Vuong Jeni¹,Chen Alexander¹,Jenkins Laurel T.²,Hu Fang²,Schmink Susanna¹,Retchless Adam C.¹^ORCID,Thomas Jennifer D.¹,Acosta Anna M.¹,McNamara Lucy A.¹,Soeters Heidi M.¹^ORCID,Mbaeyi Sarah¹,Wang Xin¹^ORCID

Affiliation:

1. Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

2. IHRC Inc., Contractor to Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

3. CDC Foundation Field Employee assigned to the Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

Abstract

The impact of serogroup B meningococcal (MenB) vaccines on carriage is not completely understood. Using whole-genome sequencing data, we assessed the diversity and distribution of MenB vaccine antigens (particularly FHbp) among 1,514 meningococcal carriage isolates recovered from vaccinated and unvaccinated students at three U.S. universities, two of which underwent MenB-FHbp mass vaccination campaigns following meningococcal disease outbreaks.

Funder

HHS | Centers for Disease Control and Prevention

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.00855-21

Reference51 articles.

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4. Anonymous. 2018. Enhanced meningococcal disease surveillance report. https://wwwcdcgov/meningococcal/downloads/NCIRD-EMS-Report-2018pdf.

5. Many carried meningococci lack the genes required for capsule synthesis and transport The GenBank accession number for the sequence of the cnl-1 allele is AJ308327.

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