HIV-Infected Macrophages Are Infected and Killed by the Interferon-Sensitive Rhabdovirus MG1

Author:

Sandstrom Teslin S.12ORCID,Ranganath Nischal12ORCID,Burke Schinkel Stephanie C.2,Salahuddin Syim345,Meziane Oussama345,Côté Sandra C.12,Costiniuk Cecilia T.346,Jenabian Mohammad-Ali567ORCID,Angel Jonathan B.128ORCID

Affiliation:

1. Department of Biochemistry, Microbiology & Immunology, University of Ottawa, Ottawa, Ontario, Canada

2. Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

3. Chronic Viral Illness Service and Division of Infectious Diseases, Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada

4. Infectious Diseases and Immunity in Global Health Program, Research Institute of McGill University Health Centre, Montreal, Quebec, Canada

5. Department of Biological Sciences, University of Quebec at Montreal (UQAM), Montreal, Quebec, Canada

6. Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada

7. Department of Microbiology, Infectiology and Immunology, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada

8. Division of Infectious Diseases, Ottawa Hospital–General Campus, Ottawa, Ontario, Canada

Abstract

Human immunodeficiency virus type 1 (HIV-1) remains a treatable, but incurable, viral infection. The establishment of viral reservoirs containing latently infected cells remains the main obstacle in the search for a cure.

Funder

Gouvernement du Canada | Canadian Institutes of Health Research

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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