Genetic Basis of Azole and Echinocandin Resistance in Clinical Candida glabrata in Japan-Reference-Cited by-同舟云学术

Genetic Basis of Azole and Echinocandin Resistance in Clinical Candida glabrata in Japan

Published:2020-08-20 Issue:9 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Khalifa Hazim O.¹²^ORCID,Arai Teppei¹,Majima Hidetaka¹,Watanabe Akira¹^ORCID,Kamei Katsuhiko¹

Affiliation:

1. Division of Clinical Research, Medical Mycology Research Center, Chiba University, Chiba, Japan

2. Department of Pharmacology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafr El-Sheikh, Egypt

Abstract

Infections caused by Candida glabrata have caused worldwide concern, especially when they are associated with increasing echinocandin and azole resistance. In this study, we analyzed the molecular mechanisms of azole and echinocandin resistance in C. glabrata isolates obtained from hospitalized patients in Japan from 1997 to 2019. All isolates were checked phenotypically for resistance and genotypically for mutations in PDR1 , ERG11 , hot spot 1 (HS1), HS2, and HS3 of FKS1 , and HS1 and HS2 of FKS2 , and all isolates were genotyped by multilocus sequence typing (MLST).

Funder

Japan Agency for Medical Research and Development

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00783-20

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