Characterization of Mice with a Platelet-Specific Deletion of the Adapter Molecule ADAP-Reference-Cited by-同舟云学术

Characterization of Mice with a Platelet-Specific Deletion of the Adapter Molecule ADAP

Published:2019-05 Issue:9 Volume:39 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Rudolph Jochen Michael¹²,Guttek Karina¹²,Weitz Gabriele¹²,Meinke Clara Antonia¹²,Kliche Stefanie¹²^ORCID,Reinhold Dirk¹²,Schraven Burkhart¹²³,Reinhold Annegret¹²

Affiliation:

1. Otto von Guericke University Magdeburg, Institute of Molecular and Clinical Immunology, Magdeburg, Germany

2. Health Campus Immunology, Infectiology and Inflammation (GC-I3), Otto von Guericke University Magdeburg, Magdeburg, Germany

3. Department of Immune Control, Helmholtz Center for Infection Research, Braunschweig, Germany

Abstract

The adhesion and degranulation-promoting adapter protein (ADAP) is expressed in T cells, NK cells, myeloid cells, and platelets. The involvement of ADAP in the regulation of receptor-mediated inside-out signaling leading to integrin activation is well characterized, especially in T cells and in platelets.

Funder

Deutsche Forschungsgemeinschaft

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00365-18

Reference50 articles.

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3. Immature hematopoietic cells display selective requirements for adhesion- and degranulation-promoting adaptor protein in development and homeostatsis