Putative TetR Family Transcriptional Regulator SCO1712 Encodes an Antibiotic Downregulator in Streptomyces coelicolor-Reference-Cited by-同舟云学术

Putative TetR Family Transcriptional Regulator SCO1712 Encodes an Antibiotic Downregulator in Streptomyces coelicolor

Published:2010-05 Issue:9 Volume:76 Page:3039-3043
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Lee Han-Na¹,Huang Jianqiang²,Im Jong-Hyuk¹,Kim Seon-Hye¹,Noh Jun-Hee¹,Cohen Stanley N.²,Kim Eung-Soo¹

Affiliation:

1. Department of Biological Engineering, Inha University, Incheon 402-751, South Korea

2. Department of Genetics, Stanford University School of Medicine, Stanford, California 94305

Abstract

ABSTRACT A tetR family transcriptional regulatory gene (SCO1712) was identified as a global antibiotic regulatory gene from a Streptomyces interspecies DNA microarray analysis. SCO1712 disruption in S treptomyces coelicolor not only upregulated antibiotic biosynthesis through pathway-specific regulators when a previously identified pleiotropic downregulatory wblA was expressed but also further stimulated antibiotic production in a wblA deletion mutant, implying that SCO1712 might encode a novel antibiotic downregulator.

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/AEM.02426-09

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