Impact of dosing schedule upon suppression of a retrovirus in a murine model of AIDS encephalopathy-Reference-Cited by-同舟云学术

Impact of dosing schedule upon suppression of a retrovirus in a murine model of AIDS encephalopathy

Published:1994-03 Issue:3 Volume:38 Page:628-631
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Bilello J A¹,Eiseman J L¹,Standiford H C¹,Drusano G L¹

Affiliation:

1. Department of Microbiology and Immunology, University of Maryland Cancer Center, Baltimore.

Abstract

We studied the impact of zidovudine (AZT) in Cas-Br-M murine leukemia virus-infected NFS-N mice after administration by once-daily bolus or continuous infusion. While higher peak concentrations of AZT were achieved by once-daily dosing, continuous AZT infusion at 25 micrograms/h maintained levels > 1 microM in plasma and > 0.2 microM in the brain. Continuous infusion provided significantly better viral inhibition, even though total doses were only one-third that of the once-daily therapy group.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.38.3.628

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