Streptococcus pyogenes TrxSR Two-Component System Regulates Biofilm Production in Acidic Environments

Author:

Isaka Masanori1ORCID,Okamoto Akira2,Miura Yutaka3,Tatsuno Ichiro1,Maeyama Jun-ichi4,Hasegawa Tadao1

Affiliation:

1. Department of Bacteriology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan

2. Department of School Health Sciences, Aichi University of Education, Kariya, Japan

3. Faculty of Wellness, Department of Nutrition, Shigakkan University, Ohbu, Japan

4. Department of Safety Research on Blood and Biological Products, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan

Abstract

Bacteria form biofilms for their protection against environmental stress and produce virulence factors within the biofilm. Biofilm formation in acidified environments is regulated by a two-component system, as shown by studies on isogenic mutants of the sensor protein of the two-component regulatory system in Streptococcus pyogenes .

Funder

MEXT | Japan Society for the Promotion of Science

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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