Development of Caspofungin Resistance following Prolonged Therapy for Invasive Candidiasis Secondary to Candida glabrata Infection-Reference-Cited by-同舟云学术

Development of Caspofungin Resistance following Prolonged Therapy for Invasive Candidiasis Secondary to Candida glabrata Infection

Published:2008-10 Issue:10 Volume:52 Page:3783-3785
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Thompson George R.¹,Wiederhold Nathan P.¹²³,Vallor Ana C.¹,Villareal Nyria C.¹,Lewis James S.¹⁴,Patterson Thomas F.¹

Affiliation:

1. University of Texas Health Science Center at San Antonio, Department of Internal Medicine, Division of Infectious Diseases, MSC 7881, 7703 Floyd Curl Drive, San Antonio, Texas 78229

2. University of Texas at Austin College of Pharmacy, 1 University Station, A1900, Austin, Texas 78712

3. University of Texas Health Science Center at San Antonio, Pharmacotherapy Education and Research Center, MSC 6220, 7703 Floyd Curl Drive, San Antonio, Texas 78299

4. Department of Pharmacy, University Health System, San Antonio, Texas 78229

Abstract

ABSTRACT We report a case of Candida glabrata invasive candidiasis that developed reduced susceptibility to caspofungin during prolonged therapy. Pre- and posttreatment isolates were confirmed to be isogenic, and sequencing of hot spots known to confer echinocandin resistance revealed an F659V substitution within the FKS2 region of the glucan synthase complex.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00473-08

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