Three Related Enzymes in Candida albicans Achieve Arginine- and Agmatine-Dependent Metabolism That Is Essential for Growth and Fungal Virulence-Reference-Cited by-同舟云学术

Three Related Enzymes in Candida albicans Achieve Arginine- and Agmatine-Dependent Metabolism That Is Essential for Growth and Fungal Virulence

Published:2020-08-25 Issue:4 Volume:11 Page:
ISSN:2161-2129
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Schaefer Katja¹²^ORCID,Wagener Jeanette²³^ORCID,Ames Ryan M.⁴^ORCID,Christou Stella²⁵⁶⁷^ORCID,MacCallum Donna M.²^ORCID,Bates Steven¹^ORCID,Gow Neil A. R.¹²^ORCID

Affiliation:

1. Medical Research Council Centre for Medical Mycology at The University of Exeter, University of Exeter, Exeter, United Kingdom

2. The Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom

3. Assay Development Scientist, Osler Diagnostics Limited, Oxford, United Kingdom

4. Department of Biosciences, University of Exeter, Exeter, United Kingdom

5. Department of Biomedical Sciences, Faculty of Science, University of Sheffield, Sheffield, United Kingdom

6. Department of Infection, Immunity and Cardiovascular Disease, Medical School, University of Sheffield, Sheffield, United Kingdom

7. Bateson Centre, University of Sheffield, Sheffield, United Kingdom

Abstract

We show that the C. albicans ureohydrolases arginase (Car1), agmatinase (Agt1), and guanidinobutyrase (Gbu1) can orchestrate an arginase-independent route for polyamine production and that this is important for C. albicans growth and survival in microenvironments of the mammalian host.

Funder

Wellcome Trust

UKRI | Biotechnology and Biological Sciences Research Council

UKRI | Medical Research Council

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.01845-20

Reference67 articles.

1. I. Arginine