Evolution towards Virulence in a Burkholderia Two-Component System-Reference-Cited by-同舟云学术

Evolution towards Virulence in a Burkholderia Two-Component System

Published:2021-08-31 Issue:4 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Schaefers Matthew M.¹²^ORCID,Wang Benjamin X.³,Boisvert Nicole M.¹,Martini Sarah J.¹,Bonney Sarah L.¹,Marshall Christopher W.⁴^ORCID,Laub Michael T.³⁵^ORCID,Cooper Vaughn S.⁴^ORCID,Priebe Gregory P.¹²^ORCID

Affiliation:

1. Division of Critical Care Medicine, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s Hospital, Boston, Massachusetts, USA

2. Harvard Medical School, Boston, Massachusetts, USA

3. Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

4. Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

5. Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

Abstract

Infections caused by members of the Burkholderia cepacia complex (BCC) are a serious concern for patients with cystic fibrosis (CF) as these bacteria are often resistant to many antibiotics. During long-term infection of CF patients with BCC, mutations in genes encoding the FixLJ system often become prevalent, suggesting that these changes may benefit the bacteria during infection.

Funder

Cystic Fibrosis Foundation

HHS | National Institutes of Health

Boston Children's Hospital

Richard and Susan Smith Family Foundation

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.01823-21

Reference69 articles.