Expansion of Vancomycin-Resistant Enterococcus faecium in an Academic Tertiary Hospital in Southwest Germany: a Large-Scale Whole-Genome-Based Outbreak Investigation

Author:

Liese Jan12ORCID,Schüle Leonard1,Oberhettinger Philipp12,Tschörner Leonie1,Nguyen Tran1,Dörfel Daniela34,Vogel Wichard3,Marschal Matthias12,Autenrieth Ingo12,Willmann Matthias12,Peter Silke12

Affiliation:

1. Institute of Medical Microbiology and Hygiene, University of Tübingen, Tübingen, Germany

2. German Center for Infection Research (DZIF), partner site Tübingen, Tübingen, Germany

3. Medical Center, Department of Hematology, Oncology, Immunology, Rheumatology and Pulmonology, University of Tübingen, Tübingen, Germany

4. Clinical Collaboration Unit Translational Immunology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), partner site Tübingen, Tübingen, Germany

Abstract

Vancomycin-resistant Enterococcus faecium (VREfm) is a frequent cause of nosocomial outbreaks. In the second half of 2015, a sharp increase in the incidence of VREfm was observed at our university medical center.

Funder

German Center for Infection Research

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference37 articles.

1. European Centre for Disease Prevention and Control. 2016. Healthcare-associated infections acquired in intensive care units—annual epidemiological report 2016. https://ecdc.europa.eu/en/publications-data/infections-acquired-intensive-care-units-annual-report-2016.

2. Enterococcal bacteraemia: factors influencing mortality, length of stay and costs of hospitalization

3. Clinical impact of antibiotic-resistant Gram-positive pathogens

4. Comparison of Mortality Associated with Vancomycin-Resistant and Vancomycin-Susceptible Enterococcal Bloodstream Infections: A Meta-analysis

5. Mechanisms of antibiotic resistance in enterococci

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