Geographic Variations in Test Reactivity for the Serological Diagnosis of Trypanosoma cruzi Infection

Author:

Truyens Carine1,Dumonteil Eric2ORCID,Alger Jackeline3,Cafferata Maria Luisa4,Ciganda Alvaro4,Gibbons Luz5,Herrera Claudia2ORCID,Sosa-Estani Sergio67,Buekens Pierre8

Affiliation:

1. Laboratory of Parasitology, Faculty of Medicine, and ULB Center for Research in Immunology (UCRI), Université Libre de Bruxelles, Brussels, Belgium

2. Department of Tropical Medicine, School of Public Health and Tropical Medicine, and Vector-Borne and Infectious Disease Research Center, Tulane University, New Orleans, Louisiana, USA

3. Instituto de Enfermedades Infecciosas y Parasitología Antonio Vidal, Departamento de Laboratorio Clínico, Hospital Escuela, Facultad de Ciencias Médicas, UNAH, Tegucigalpa, Honduras

4. Unidad de Investigación Clínica y Epidemiológica Montevideo (UNICEM), Montevideo, Uruguay

5. Institute for Clinical Effectiveness and Health Policy, Buenos Aires, Argentina

6. Drugs for Neglected Diseases initiative-Latin America, Rio de Janeiro, Brazil

7. Epidemiology and Public Health Research Center (CIESP-CONICET), Buenos Aires, Argentina

8. Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, USA

Abstract

Chagas disease is a neglected disease caused by Trypanosoma cruzi parasites. Most diagnosis is based on serological tests, but the lack of a gold standard test complicates the measurement of test performance.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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