Affiliation:
1. Laboratorio de Síntesis Orgánica y Productos Naturales, Centro de Química
2. Laboratorio de Micología, Centro de Microbiología y Biología Celular, Instituto Venezolano de Investigaciones Científicas, Caracas 1020A, Venezuela
Abstract
ABSTRACT
We studied the antiproliferative effects of three azasterol analogs [piperidyl-2-yl-5α-pregnan-3β,20(
R
)-diol (AZA-1), 22-piperidin-2-yl-pregnan-22(
S
),3β-diol (AZA-2), and 22-piperidin-3-yl-pregnan-22(
S
),3β-diol (AZA-3)] and their effects on the lipid composition of the pathogenic yeastlike phase of the dimorphic fungus
Paracoccidioides brasiliensis
. Inhibition was 100% for AZA-1 at 5 μM, 62% for AZA-2 at 10 μM, and 100% for AZA-3 at 0.5 μM. The analogs inhibited different stages of the sterol biosynthesis pathway.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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