Affiliation:
1. Center for Infectious Diseases and Travel Medicine, Department of Medicine, University Hospital, Freiburg, Germany
Abstract
ABSTRACT
Several arylpiperazines capable of reversing multidrug resistance (MDR) in
Escherichia coli
overexpressing
acrAB
and
acrEF
but not in pump-deficient mutant strains were identified. 1-(1-Naphthylmethyl)-piperazine, one of the more active compounds, enhanced susceptibility to fluoroquinolones and other agents and increased the intracellular concentration of levofloxacin and ethidium bromide, suggesting efflux pump inhibition as the mechanism of MDR reversal.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
200 articles.
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