Furazolidone- and Nitrofurantoin-Resistant Helicobacter pylori : Prevalence and Role of Genes Involved in Metronidazole Resistance-Reference-Cited by-同舟云学术

Furazolidone- and Nitrofurantoin-Resistant Helicobacter pylori : Prevalence and Role of Genes Involved in Metronidazole Resistance

Published:2001-01 Issue:1 Volume:45 Page:306-308
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Kwon Dong H.¹,Lee Miae¹,Kim J. J.²,Kim J. G.³,El-Zaatari F. A. K.¹,Osato M. S.¹,Graham D. Y.¹⁴

Affiliation:

1. Department of Medicine1 and

2. Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine,2 and

3. Guro Hospital, Korea University,3 Seoul, Korea

4. Division of Molecular Virology,4 Baylor College of Medicine and Veterans Affairs Medical Center, Houston, Texas 77030, and

Abstract

ABSTRACT The prevalence of furazolidone, nitrofurantoin, and metronidazole resistance among Helicobacter pylori strains was assessed with 431 clinical isolates. Fifty-two percent were metronidazole resistant, compared to 2% (7 of 431) with resistance to furazolidone and nitrofurantoin. All seven furazolidone- and nitrofurantoin-resistant isolates were also metronidazole resistant. rdxA , frxA , and fdxB knockouts did not result in furazolidone or nitrofurantoin resistance. These data suggest that furazolidone and nitrofurantoin may be good alternatives to metronidazole for treating H. pylori infection.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.45.1.306-308.2001

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