Radioresistance of Deinococcus radiodurans: functions necessary to survive ionizing radiation are also necessary to survive prolonged desiccation

Author:

Mattimore V1,Battista J R1

Affiliation:

1. Department of Microbiology, Louisiana State University, Baton Rouge 70803, USA.

Abstract

Forty-one ionizing radiation-sensitive strains of Deinococcus radiodurans were evaluated for their ability to survive 6 weeks of desiccation. All exhibited a substantial loss of viability upon rehydration compared with wild-type D. radiodurans. Examination of chromosomal DNA from desiccated cultures revealed a time-dependent increase in DNA damage, as measured by an increase in DNA double-strand breaks. The evidence presented suggests that D. radiodurans' ionizing radiation resistance is incidental, a consequence of this organism's adaptation to a common physiological stress, dehydration.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Reference20 articles.

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2. Deoxyribonucleic acid strand breaks during drying of Escherichia coli on a hydrophobic membrane;Asada S.;Appl. Environ. Microbiol.,1979

3. Correlation of bacterial sensitivities to ionizing radiation and mild heating;Bridges B. A.;J. Gen. Bacteriol.,1969

4. Survival in extreme dryness and DNA-single strand breaks;Dose K.;Adv. Space Res.,1992

5. DNA-strand breaks limit survival in extreme dryness;Dose K.;Origins Life Evol. Biosphere,1991

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