Genome Sequence of Human Cytomegalovirus Ig-KG-H2, a Variant of Strain KG Propagated in the Presence of Neutralizing Antibodies-Reference-Cited by-同舟云学术

Genome Sequence of Human Cytomegalovirus Ig-KG-H2, a Variant of Strain KG Propagated in the Presence of Neutralizing Antibodies

Published:2020-04-23 Issue:17 Volume:9 Page:
ISSN:2576-098X
Container-title:Microbiology Resource Announcements
language:en
Short-container-title:Microbiol Resour Announc

Author:

Al Qaffas Ahmed¹,Camiolo Salvatore²,Nichols Jenna²,Davison Andrew J.²,Ourahmane Amine¹,Cui Xiaohong¹,Schleiss Mark R.³,Hertel Laura⁴,Dittmer Dirk P.⁵,McVoy Michael A.¹

Affiliation:

1. Department of Pediatrics, Virginia Commonwealth University, Richmond, Virginia, USA

2. MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom

3. Center for Infectious Diseases and Microbiology Translational Research, Division of Pediatric Infectious Diseases, Minneapolis, Minnesota, USA

4. Department of Pediatrics, School of Medicine, University of California, San Francisco, Oakland, California, USA

5. Lineberger Comprehensive Cancer Center Program in Global Oncology, Department of Microbiology and Immunology, Center for AIDS Research, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

Abstract

Human cytomegalovirus shed in infant urine was isolated and serially passaged in fibroblasts in the presence or absence of neutralizing antibodies. Comparison of the genome sequences of representative viruses Ig-KG-H2 (passed with antibody) and ϕ-KG-B5 (passed without antibody) revealed the presence of several mutations in each virus.

Funder

HHS | National Institutes of Health

Merck

March of Dimes Foundation

Wellcome Trust

UKRI | Medical Research Council

Publisher

American Society for Microbiology

Subject

Genetics,Immunology and Microbiology (miscellaneous),Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MRA.00063-20