A Novel Potentially Recombinant Rodent Coronavirus with a Polybasic Cleavage Site in the Spike Protein-Reference-Cited by-同舟云学术

A Novel Potentially Recombinant Rodent Coronavirus with a Polybasic Cleavage Site in the Spike Protein

Published:2021-10-27 Issue:22 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Li Xin¹²,Wang Liang³,Liu Peipei²,Li Hongying⁴,Huo Shuting¹²,Zong Kexin¹²,Zhu Shiyan¹²,Guo Yuanyuan²⁵,Zhang Libiao⁶,Hu Ben⁷,Lan Yu²,Chmura Aleksei⁴^ORCID,Wu Guizhen²,Daszak Peter⁴,Liu William J.¹²⁸^ORCID,Gao George F.¹²³^ORCID

Affiliation:

1. School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, China

2. NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China

3. CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

4. EcoHealth Alliance, New York, New York, USA

5. School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, China

6. Institute of Zoology, Guangdong Academy of Sciences, Guangzhou, China

7. CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China

8. Research Units of Adaptive Evolution and Control of Emerging Viruses, Chinese Academy of Medical Sciences, Beijing, China

Abstract

Surveillance of viruses among rodents in rural and urban areas of South China identified three rodent coronaviruses, RCoV-GCCDC3, RCoV-GCCDC4, and RCoV-GCCDC5, one of which was identified as a novel potentially recombinant coronavirus with a polybasic cleavage site in the spike (S) protein. Through reverse transcription-PCR (RT-PCR) screening of coronaviruses, we found that coronavirus prevalence in urban areas is much higher than that in rural areas.

Funder

Excellent Young Scientist Program of the Natural Science Foundation of China

the Major Special Projects for Infectious Disease Research of China

Research Units of Adaptive Evolution and Control of Emerging Viruses

NSFC | Foundation for Innovative Research Groups of the National Natural Science Foundation of China

United States Agency for International Development

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01173-21