Methyltransferase-like 3 Modulates Severe Acute Respiratory Syndrome Coronavirus-2 RNA N6-Methyladenosine Modification and Replication-Reference-Cited by-同舟云学术

Methyltransferase-like 3 Modulates Severe Acute Respiratory Syndrome Coronavirus-2 RNA N6-Methyladenosine Modification and Replication

Published:2021-08-31 Issue:4 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Zhang Xueyan¹²,Hao Haojie³⁴⁵,Ma Li¹²,Zhang Yecheng¹²,Hu Xiao¹²,Chen Zhen¹,Liu Di¹,Yuan Jianhui⁶,Hu Zhangli³,Guan Wuxiang¹^ORCID

Affiliation:

1. Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China

2. University of Chinese Academy of Sciences, Beijing, China

3. College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, China

4. College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, China

5. Hanshan Normal University, Chaozhou, China

6. Nanshan District Center for Disease Control and Prevention, Shenzhen, China

Abstract

Internal chemical modifications of viral RNA play key roles in the regulation of viral replication and gene expression. Although potential internal modifications have been reported in SARS-CoV-2 RNA, the function of the SARS-CoV-2 N6-methyladenosine (m 6 A) modification in the viral life cycle is unclear.

Funder

Ministry of Science and Technology

Chinese Academy of Sciences Key Project

Chinese Academy of Engineering

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.01067-21

Reference71 articles.

1. Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia